Narcolepsy is the direct indication for the usage of Modafinil drug. Narcolepsy is the disease that affects human nervous system and gives ruse to sleep function disturbance.

Narcolepsy can manifest through one or several symptoms, depending on the disease’s development degree.

How Does Narcolepsy Show Up?

Suddenly appearing daytime sleepiness and paroxysms of sudden falling asleep in the daytime

Normally, this symptom is one of those that appear early. Sleepiness appears suddenly and the patient isn’t able to control these paroxysms. Thus, the person can fall asleep not just against their wishes, but even in an absolutely inappropriate environment.

This is specifically dangerous in case, when professional activity of the patient is associated with things that require advanced attention. Daytime falling asleep can repeat several times a day and their duration ranges from several seconds to a few minutes.

Sleepiness paroxysm begins with gradual speech deceleration, then the neck muscles get relaxed, and then follows complete shutdown of consciousness. However, the patient can manage to take a pose comfortable for sleeping, as a rule.

Even if the patient feels cheerfulness and burst of energy after awakening, sleepiness comes back a few hours later.

Cataplexy

This is an affective muscle tone loss, a tone blockage, leading to the patient falling unconscious in pronounced cases.

Paroxysm of sudden weakness can appear, when the person experiences strong emotions of any kind, whether positive or negative.

Strong laughter, amazement, sexual intercourse, anger, crying, and other emotions can become a reason of a cataplexy paroxysm. The paroxysm can develop so fast that the patient can fall down and get an injury.

Duration of the cataplexy paroxysm ranges from a few seconds to several minutes. Then, the person can fall asleep.

Hypnagogic and Hypnopompic Hallucinations

Hypnagogic hallucinations appear during falling asleep, whereas hypnopompic hallucinations can appear during awakenings. They represent bright visions of an acoustic or visual nature, similar to dreams.

The person understands that they are not asleep yet, but starts seeing a dream. Hallucinations (visions) merge with the environment. The patient can start seeing people or fairy tale characters walking around the room. They can also hear voices, music, or see bright light flashes. As a rule, such visions are followed by fear and anxiety.

Sleep Numbness

After awakening, the narcolepsy patient can experience a condition of complete immobility, although remaining conscious. The person adequately appraises the situation, but is not able to move. They only have a possibility to blink and move their eyes.

Sleep numbness appears in the morning most often, after nighttime sleep, but can also appear in the evening or at night. In this condition, the patient feels very uncomfortable, because sleep numbness can be followed with hallucinations.

Paralysis paroxysm can last from a few seconds to several minutes and end up by gradual movement control acquiring.

Narcolepsy Treatment

Narcolepsy is a heavy disease, which prevents the patient to maintain active life rhythm and impedes their social adaptation. It is yet impossible to completely cure narcolepsy, but there are medicines that can prevent sleepiness paroxysms, helping the person maintain cheerfulness. Modafinil is exactly the medicine from this category.

Modafinil Dosage in Narcolepsy

Modafinil drug should be taken inside, perorally, not chewed, and washed down with the necessary amount of liquid.

Average Modafinil drug effect period is 8 hours. However, depending on individual organism specifications and metabolism turnaround, effect of Modafinil drug can last much less (about 6 hours) or longer (10 hours).

Daily Modafinil dosage in narcolepsy consists of 200 mg. It is better to divide Modafinil 200 mg on two portions. Modafinil tablet is taken one time a day – in the morning, to overcome uncontrolled sleepiness paroxysms.

The next Modafinil 100 mg dosage in narcolepsy is taken after lunch. In narcolepsy, it is not recommended to take Modafinil 100 mg in the evening, since an additional Modafinil dosage, even in narcolepsy, can affect the change of sleeping schedule and cause insomnia.

After the doctor prescribes a Modafinil dosage for narcolepsy treatment and issues the prescription, you are able to buy Modafinil with prescription, in any pharmacy in your town. Since Modafinil has received a wide application, there is a possibility to buy Modafinil in Canada, buy Modafinil in US, buy Modafinil in UK, buy Modafinil in Europe, buy Modafinil in India, and other countries. IF due to some reasons, you don’t have a prescription, there is a possibility to buy Modafinil without prescriptions in online pharmacies.

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Modafinil is a medicine that possesses a strong tonic effect on a human organism. Modafinil drug removes the feeling of fatigue and sleepiness, promoting the improvement of working efficiency.

Direct indications towards the use of Modafinil dosage are the diseases associated with a sleep function disorder, notably with the increased sleepiness. In particular, Modafinil drug is recommended for use in hypersomnia.

Hypersomnia is distinguished by the increase of sleep duration a quarter from regular time, which was sufficient for a person to have a good sleep. Moreover, they are feeling sleepy and tired for the course of the day, and after sleeping they still continue to feel fatigue and tiredness.

Hypersomnia can have a temporary nature, appearing in healthy people as a result of overfatigue. For example, after not getting enough of sleep or having excessive physical tension for several days or nights in a row.

However, if hypersomnia has a protracted nature, it can be a sign of a serious disease.

Diseases That Have Hypersomnia as a Symptom

• Mental disorder. When a person is in a condition of deep anxiety or depressed state;
• Lack of oxygen in the body;
• Increase of carbon dioxide concentration in the organism following sleep apnea;
• Soporific drugs overdose;
• Various brain diseases;
• Narcolepsy (especially, if hypersomnia started as far back as in childhood).

Hypersomnia Diagnosis

In order diagnose hypersomnia, it is necessary to refer to a specialist. The doctor has to know how long the increased sleepiness has started and what factors have preceded it, and also which medicines are taken by the patient. Also, the specialist will refer the patient to the general medical examination.

Moreover, since hypersomnia can be a symptom of various diseases, it will be necessary to check cardiac performance, lung functions, and liver work and to go through various laboratory tests.

Suddenly appeared  hypersomnia can be a sign of a bad form of depression or neurological disease (encephalitis, meningitis, brain tumor, etc.)

Neurologist consultation will help to determine depression, memory disorder, or pathological neurologic symptoms. Also, the patient could be offered to go through a computed tomography scan (CT) or magnetic resonance image (MRI).

Hypersomnia Treatment

The patient should be provided with the appropriate conditions for adequate night sleep duration. Also, in many cases, the termination of stress factor influence result in improvement.

Medicamental therapy adds up to the use of medicines capable of controlling sleep function and remove excess sleepiness and fatigue. Modafinil is one of these medicines.

Initial Modafinil dosage in hypersomnia consists of 100 mg. Modafinil pill of 100 mg should be taken in the morning, the beginning of a working day, to prevent sleepiness paroxysms.

The effect of Modafinil pill of 100 mg continues for 8 hours. It is not recommended to take a Modafinil dosage before going to bed, because it can result in insomnia.

In dependence upon patient’s individual organism peculiarities, Modafinil dosage can be increased up to 200 mg a day. In this case, a Modafinil pill of 100 mg is taken in the morning and after lunchtime.

Normally, a Modafinil pill of 100 mg allows maintaining wakefulness and working efficiency for the course of entire working day.

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Modafinil is a nootropic medicine. It stimulates the brain’s activity, promotes the improvement of attention concentration and the increase of working efficiency in periods, when it’s necessary to focus on some kind of physical or mental activity, but there’s no time for rest.

Narcolepsy is the direct indication towards the use of Modafinil. When having this disease, the patient loses control over sleep function and can fall asleep during the day, not accounting for it. Modafinil dosage removes paroxysms of sleepiness and helps the patient carry on a normal life style.

Considering the high chances of Modafinil dosage to affect the energetic tone of the organism, some people can buy Modafinil in situations, when it is necessary to prolong their wakeful condition without losing mental and physical durability.

Since modafinil is a medicine that stimulates human nervous system, it is necessary to familiarize with modafinil drug interaction before taking a modafinil dosage.

Modafinil Drug Interactions – Monoamine Oxidase Inhibitors

During the use of modaifinil, it is recommended to abstain from the use of monoamine inhibitor use. They include furazolidone, linezolid, isocarboxazid, moclobemide, phenelzine, selegiline, procarbazine, and tranylcypromine.

In a number of cases, modafinil drug interactions with monoamine oxidase inhibitors can have a fatal nature and lead to severe negative consequences for human health.

The use of monoamine oxidase is prohibited not only during the use of modafinil dosage, but also the two weeks before using modafinil and two weeks after the use of modafinil dosage.

Modafinil Drug Interactions – Steroid Contraceptives

Modafinil can affect the assimilation of hormonal contraceptives. Therefore, if you are using hormonal contraceptives as the only way to prevent undesired pregnancy, you would need to use additional means.

Modafinil drug interactions reduce hormonal contraceptive efficiency. When using contraception pills, plasters containing a dose of hormones, or the ring to prevent unwanted pregnancy, specialists advise to use barrier contraception as an obligatory addition to these methods. In other words, you would need to use condoms.

Modafinil drug interactions with steroid contraceptives consist in the possibility of hormonal medicine effect reduction up to a month. Therefore, using a barrier method of contraception when having sexual intercourses is necessary not only during the use of Modafinil dosage, but also during a month after modafinil dosage discontinuance.

Modafinil Drug Interactions and Antidepressants

Since modafinil affects the activity of liver enzymes, modafinil dosage can either accelerate or decelerate the excretion of medicines out off the human organism. This modafinil drug interaction is revealed by a number of antidepressants, including clopiramine, desipramine, fluoxetine, cyclosporine, diazepam, fluvoxamine, phenytoin, propranolol, triazolam, and theophylline.

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If you compare Adderall vs modafinil, you can notice that both of these medicines differ by contents, pharmacological action, and they also belong to the different medical drug groups.

Adderall vs Modafinil – Drug Class

Modafinil’s drug class is CNS stimulants. By its pharmacological action, Modafinil drug also belongs to nootropics, substances that can temporarily improve human mental and physical functions.

Adderall is an amphetamine. Adderall contains racemic amphetamine aspirate monohydrate, racemic amphetamine sulfate, dextroamphetamine saccharide, and dextroamphetamine sulfate, all of which are amphetamine salts.

Adderall vs Modafinil – Usage Indications

Adderall vs Modafinil differ not only by their contents, but they also have different usage indications.

Modafinil drug direct usage indication is narcolepsy, hypersomnia, and night apnea.

Adderall’s direct usage indication is also narcolepsy, but the indications also include attention deficiency syndrome with hyperactivity. Studies of modafinil drug as a medical drug, which can be used in attention deficiency syndrome, are currently being continued. Specialists have no ultimate data considering this matter yet.

Adderall vs Modafinil – Side Effects

If you compare Adderall vs modafinil by the amount of side effects, you will see that modalert side effects occur very rarely and carry a not fatal nature, if the recommended modafinil dosage schedule is complied with.

Hereby, Modafinil side effects can include: headache and lightheadedness, dry mouth, nausea, and weight loss.

Adderall has more side effects, than modafinil. Besides, in 2005 Ministry of Public Health of Canada suspended the distribution of Adderall XR on the ground of the data, which evidenced that the use of Adderall XR has lead to fatal outcome in 12 pediatric patients. During the researches it was revealed that the use of Adderall has lead to the increased risk of cardiac defect. Several months after, Ministry of Public Health of Canada lifted a ban on distribution and usage of Adderall XR, relying on the data about the amount of sudden death in children was insignificant and could have a random character.

However, it has been known for a long time that a lengthy use of amphetamines can lead to depression, irritability, increased fatigability, addition, and even amphetamine psychosis.

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Comparing Modafinil vs. caffeine as means that help maintain the energetic tone of the body, it is noticeable that they have a nice set of differences.

Modafinil vs. Caffeine – Mechanism of Action

Caffeine belongs to psychostimulants, the preparations that cause an expressed exciting effect to respiratory and vasomotor centers of medulla oblongata. Caffeine regulates excitement processes in the brain, ipso facto intensifying positive conditioned reflexes and increasing motor activity.

Modafinil drug is closer to nootropics by its effect. These medicines cause influence on education, improve memory and mental activity, and increase brains durability towards aggressive affections. Modafinil increases the release of monoamines, while elevating the level of hypothalamic histamines.

Modafinil vs. Caffeine – the effect caused by Modafinil drug on cardiovascular system is much lower, than the effect of caffeine.

Caffeine causes expressed stimulant influence on cardiovascular system. Its action provokes increased rates and intensity of heart beats. During the trials of Modafinil drug in healthy volunteers, it was noticed that even upon exceeding the recommended daily dose of Modafinil 400 mg, the increase of rate and intensity of heart beats hasn’t been observed.

Modafinil vs. Caffeine – Action Efficiency

Modafinil vs. caffeine excels the latter in the effect duration. Caffeine’s action effect continues for 2-3 hours, depending on a person’s individual organism’s reaction. One Modafinil dosage of 100 mg is effective for 8 hours.

As an energetic, Modafinil vs. caffeine causes a more invigorating effect on the body. After taking Modafinil 200 mg, sleepiness gets removed for the course of 16 hours. During this period, a person doesn’t experience the need for sleep at all. But, the speed of reactions and mental productivity remain proper. Invigorating effect of caffeine is less perceived. After taking the highest daily caffeine dose of 300 mg, a person can continue experiencing the desire to sleep and feel fatigue along with irritability.

Modafinil 200 mg completely removes the feeling of sleepiness and fatigue for 8-16 hours, while caffeine simply dulls them. Comparing Modafinil vs. caffeine efficiency, it becomes obvious that the invigorating effect of Modafinil drug is much more expressed, than after taking caffeine.

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Modafinil was discovered in the 70’s of the previous century. Today, Modafinil drug is used for the treatment of narcolepsy. Modafinil drug helps overcome paroxysms of uncontrolled sleepiness, which are regularly experienced by narcolepsy patients. However, it was revealed that Modafinil also causes an invigorating effect on healthy people. After taking a Modafinil dosage, a person is capable to work productively for more than 24 hours and not experience the need for sleep.

Modafinil drug possesses a wide range of action and the studies of Modafinil are still being continued. It was established that Modafinil can affect weight loss. During Modafinil drug testing, it was revealed that Modafinil can suppress appetite as effective as amphetamines. Furthermore, Modafinil side effects are much less than those of amphetamines. For instance, a Modafinil dosage 100 mg doesn’t cause heart rate increase.

Modafinil weight loss occurs due to the fact that the person stops experiencing the feeling of hunger. Modafinil dosage 100 mg helps to suppress appetite for 8 hours. This is the exact duration of Modafinil drug effect.

Weight loss tablets that suppress appetite affect centers of hunger and satiety, which are located in the brain. Nervous system activity can be brought to the electric impulse transmission from one cell to another and from nervous cells to the cells of other tissues. This transmission is performed due to chemical substances, known as mediators. Different mediators have their own roles in different structures of the brain. As a rule, weight loss pills can be divided in two groups. Tablets in the first group stimulate serotonin generation, whereas the second group tablets promote the generation of adrenaline. But Modafinil weight loss is completely different. Modafinil stimulates the release of monoamines (catecholamines, norepinephrine, and dopamine), while affecting hypothalamic histamines.

Modafinil dosage doesn’t only suppress the feeling of hunger and promote Modafinil weight loss. Modafinil dosage increases organism’s entire energetic tone. Thus, if a person uses Modafinil for weight loss, they don’t feel weakness and increased fatigue, which can appear upon the reduction of the amount of calories consumed.

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The modern world dictates its own rules. In order to become successful, we have to have time for everything. In the end, we are always rushing somewhere, but don’t always make it. No time to rest is left, but the body can’t handle such load. As a result, we are experiencing chronic fatigue, becoming resentful, and losing the opportunity to achieve our goals.

However, there are solutions that can help to get out of this critical situation. Certain medicines possess an effect, which helps to discard of the necessity to sleep for a certain period. At the same time, mental and physical load are OK, because these processes are improving under the influence of the medicine.

Modafinil helps to fight such an unpleasant disease, like narcolepsy already for many years. Narcolepsy patient frequently experiences uncontrolled sleepiness paroxysms and can fall asleep during the day, even if they are occupied with something at that moment. Modafinil effect consists in the temporary sleepiness “cutoff”. After taking Modafinil dosage of 200 mg, narcolepsy patients stop experiencing sleepiness paroxysms in the inappropriate time.

Modafinil causes an energetic effect on healthy people. The need to sleep and rest temporarily gets lower. The action of modafinil drug persists for eight hours and the patient experiences a burst of wakefulness during this period, they can fruitfully occupy with mental and physical labor throughout the day. It is possible to take Modafinil 100 mg every 8 hours for this purpose.

Modafinil is not a psychical stimulant, as it is closer to the nootropics by its features. Nootropics are natural substances that improve mental processes.

Modafinil drug has the minimal side effects among medicines with the similar action.

You can learn more about the mechanism of action of Modafinil drug by reading a Modafinil review.

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Modafinil effect persists for about eight hours. During the effect of Modafinil, the person stops feeling sleepiness, and feels wakefulness and increased working efficiency. Modafinil drug should be taken internally, perorally, not chewed. It is desireable to wash a Modafinil pill down with the necessary about of water.

It is not advised to wash Modafinil down with coffee, tea, or coca-cola. Throughout the action of Modafinil effect, it is advised to abstain from any drinks containing caffeine. Interaction of Modafinil and caffeine can cause side effects.

Ingestion doesn’t affect the assimilation of Modafinil in the body.

Modafinil Dosage in Narcolepsy

Since the direct Modafinil usage indication is narcolepsy, the recommended Modafinil dosage is associated with this disease.

Modafinil dosage in narcolepsy consists of 200 mg daily. Modafinil pill of 100 mg has to be taken in the morning in order to prevent sleepiness paroxysms that accompany narcolepsy throughout the day. The second Modafinil dosage in narcolepsy is also 100 mg and should be taken after lunch. It is not recommended to take Modafinil dosage before going to sleep, since it can lead to insomnia.

Modafinil Dosage in Sleep Disorder Caused by Working in Shifts Schedule

If you suffer from a sleep disorder caused by working in shifts schedule, it is recommended to take Modafinil dosage of 100 mg one hour before your working shift starts. Taking one more Modafinil dosage during the working time is pointless, because Modafinil effect persists for 8 hours.

Modafinil Dosage for Energetic Tone Increase

It is possible to take Modafinil dosage in the absence of narcolepsy, if you want to intensify your working efficiency and refuse sleeping temporarily. It is recommended to take the first Modafinil dosage of 100 mg in the morning. If there is a necessity to prolong Modafinil effect, you can take one more Modafinil dosage of 100 mg after 8 hours. The highest daily Modafinil dosage is 400 mg.

Modafinil Dosage in Children

Modafinil is contraindicated for use in children, so no Modafinil dosage is indicated for children.

Modafinil Dosage in Euphoria

As opposed to amphetamines, taking Modafinil doesn’t cause euphoria, even when the recommended Modafinil dosage is increased.

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Modafinil is a nootropic used for the treatment of narcolepsy. Modafinil affects healthy people as an energetic, suppressing sleepiness and increasing working efficiency in periods, when there’s no time left to rest. But, not depending on the fact that Modafinil can be used by healthy people, it is a medicine and this means it possesses a number of usage contraindications.

Modafinil Usage Contraindications

• Modafinil drug cannot be used by children or adolescents. Clinical trials of modafinil drug are being continued, and this is why there is no unequivocal information about the safety of modafinil drug employment in children;
• Modafinil dosage can cause unwanted skin reactions, thus and so it is contraindicated in patients, who suffer allergies on medicines, especially modafinil;

Pregnancy and lactation. The effect on intrauterine fetus formation after taking modafinil and the question of modafinil dose release during lactation is still being studied. Therefore, pregnant and breastfeeding women should abstain from taking modafinil dose in any portions.

The use of modafinil drug should obligatory be coordinated with the doctor in case of presence of mental disorders. If a patient has a disposition to various phobias, taking modafinil dose might worsen the clinical course.

It is not recommended to take modafinil if any liver diseases are present, especially cirrhosis (a cicatricial shrinkage and deformation of the organ due to infectious diseases, intoxications, metabolism malfunctions, and other reasons).

Modafinil drug is contraindicated, when the patient has hypertrophic cardiomyopathy (an autosomal dominant disease characterized by the ventricle wall thickening).

Taking modafinil drug is prohibited in patients that have the diagnosis of mitral valve prolapse (the disease followed by malfunction of the valve located between the left atrium and the ventricle).

If you suffer from any cardiovascular diseases, you should get a doctor consultation before starting to use Modafinil drug. Upon the exposure of kidney diseases, you might need to adjust your modafinil dose.

Modafinil abuse can lead to the appearance of modafinil side effects and even to overdose.

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When considering the matter of Methylphenidate vs modafinil it is necessary to comprehend that the both medicines, although possessing a resembling effect, belong to different groups. Indeed, modafinil and Methylphenidate are able to improve the body’s energetic tone, improve working efficiency, and remove fatigue and sleepiness. However, Methylphenidate is a psychostimulant standing in the same row with amphetamines, cocaine, and morphine. Modafinil, by its pharmacological action, is more similar to the nootropics and, hence, possesses a much less toxicity, than Methylphenidate.

In order to notice modafinil’s advantage over Methylphenidate, it is enough to compare side effects of these two medicines.

Modafinil side effects:

• Headache;
• Lightheadedness;
• Insomnia;
• Nausea;
• Dry mouth;
• Weight loss.

Modafinil side effects appear on extremely rare occasions, in the majority of cases after a lengthy uninterruptable taking of the highest daily Modafinil dosage of 400 mg, or after exceeding of the recommended Modafinil dosage. Modafinil side effects pass very quickly, if employment of the medicine is discontinued or Modafinil dosage is reduced.

Methylphenidate vs modafinil has much more side effects, which can be both quickly appearing and those appearing with the lapse of time.

Quickly appearing Methylphenidate side effect:

• Loss of appetite;
• Heartbeat acceleration;
• Pressure elevation;
• Body temperature increase;
• Sleeping schedule malfunction;
• Changeable and aggressive behavior;
• Hallucinations;
• Hyperexcitability;
• Irritability.

Methylphenidate side effects that can appear with the lapse of time:

Irreversible damage to blood vessels of heart and brain. These destructions can lead to a stroke, heart attacks, and even lethal outcome;

Damage to the viscera, including kidneys, liver, and lungs;

Diseases of respiratory tracks and destruction of nose tissues because of the medicine inhalation;

Employment of Methylphenidate provokes addiction and may also develop the propensity for other narcotic drugs, because it will be necessary to increase Methylphenidate dosage in order to support euphoric condition.

Considerable Methylphenidate doses may lead to convulsions, paroxysms, and lethal outcome. In the meantime, after taking high Modafinil dosages, side effects don’t always appear.

The fact that Methylphenidate has more side effects upon the Methylphenidate vs modafinil comparison can be explained by another fact, which is that modafinil is a new generation medicine. Modafinil was synthesized in 1973 and only got to market in 1994. On the other hand, Methylphenidate was invented much earlier – in 1944.

Methylphenidate vs modafinil – usage indications difference

Methylphenidate is prescribed in cases of attention deficiency syndrome, highly socialized autism forms, orthostatic tachycardia, apathy, and narcolepsy. Narcolepsy and hyposomnia are the direct modafinil usage indications. At this juncture, modafinil researches are being continued, considering it as a medicine against depression, attention deficiency syndrome, and the Alzheimer’s disease.

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